STUDIES ON AMINO-ACID ANHYDRIDES, I. MOLECULAR COMPOUNDS OF DIKETOPIPERAZINE WITH COPPER HALIDES

Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides.

Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc(2)O and MgCl(2).

Terpolymerization kinetics of amino acid N-carboxy anhydrides

Based on their versatility with respect to amino acid type and sequence, polypeptides have become attractive for a number of biological applications such as drug delivery, biomineralization, and drugs. N-carboxy anhydride (NCA) polymerization is a convenient way to rapidly prepare high-molecular weight polypeptides with good control over molecular weight and polydispersity. However, the kinetic...

Carboxylic acid anhydrides via Pd-catalyzed carbonylation of aryl halides at atmospheric CO pressure.

A convenient method has been developed, which allows for the direct transformation of aryl iodides into the corresponding carboxylic acid anhydrides via Pd-catalyzed carbonylation under atmospheric CO pressure.

Copper(I)-Catalyzed Coupling of Terminal Acetylenes with Aryl or Vinyl Halides Copper(I)-Catalyzed Coupling of Terminal Acetylenes

Studies on uric acid and related compounds. I. Quantitative determination of uric acid in biological fluids.

The available methods of determination of uric acid can be divided into three main groups: (a) the direct determination of the reducing power of uric acid; (b) the coprecipitation of the uric acid or its adsorption on a precipitating material, dissolving the acid, and determination of its reducing power; and (c) quantitative decomposition of uric acid by uricase. A survey of these methods has b...